Computational Studies towards the Identification of Novel Rhodopsin-Binding Compounds as Chemical Chaperones for Misfolded Opsins

Accumulation of misfolded and mistrafficked rhodopsin on the endoplasmic reticulum of photoreceptor cells has a pivotal role in the pathogenesis of retinitis pigmentosa and a subset of Leber’s congenital amaurosis. One potential strategy to reduce rhodopsin misfolding and aggregation in these condit...

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Detalles Bibliográficos
Autores principales: Pasqualetto, Gaia, Schepelmann, Martin, Varricchio, Carmine, Pileggi, Elisa, Khogali, Caroline, Morgan, Siân R., Boostrom, Ian, Rozanowska, Malgorzata, Brancale, Andrea, Ferla, Salvatore, Bassetto, Marcella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660337/
https://www.ncbi.nlm.nih.gov/pubmed/33114011
http://dx.doi.org/10.3390/molecules25214904

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660337/
https://www.ncbi.nlm.nih.gov/pubmed/33114011
http://dx.doi.org/10.3390/molecules25214904

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