New insights into the function of mammalian Argonaute2

Uncovering the mechanisms that recognise a microRNA (miRNA) target is 1 of the biggest challenges because the Ago–miRNA complex is able to overcome different derogations of complementarity when binding targets. However, the recently solved crystallographic structure of Argonaute2 (Ago2) and a high-t...

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Detalles Bibliográficos
Autor principal: Marzec, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660459/
https://www.ncbi.nlm.nih.gov/pubmed/33180792
http://dx.doi.org/10.1371/journal.pgen.1009058
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author Marzec, Marek
author_facet Marzec, Marek
author_sort Marzec, Marek
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description Uncovering the mechanisms that recognise a microRNA (miRNA) target is 1 of the biggest challenges because the Ago–miRNA complex is able to overcome different derogations of complementarity when binding targets. However, the recently solved crystallographic structure of Argonaute2 (Ago2) and a high-throughput analysis that used repurposed sequencing techniques has brought us closer to achieving this goal.
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spelling pubmed-76604592020-11-18 New insights into the function of mammalian Argonaute2 Marzec, Marek PLoS Genet Review Uncovering the mechanisms that recognise a microRNA (miRNA) target is 1 of the biggest challenges because the Ago–miRNA complex is able to overcome different derogations of complementarity when binding targets. However, the recently solved crystallographic structure of Argonaute2 (Ago2) and a high-throughput analysis that used repurposed sequencing techniques has brought us closer to achieving this goal. Public Library of Science 2020-11-12 /pmc/articles/PMC7660459/ /pubmed/33180792 http://dx.doi.org/10.1371/journal.pgen.1009058 Text en © 2020 Marek Marzec http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Marzec, Marek
New insights into the function of mammalian Argonaute2
title New insights into the function of mammalian Argonaute2
title_full New insights into the function of mammalian Argonaute2
title_fullStr New insights into the function of mammalian Argonaute2
title_full_unstemmed New insights into the function of mammalian Argonaute2
title_short New insights into the function of mammalian Argonaute2
title_sort new insights into the function of mammalian argonaute2
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660459/
https://www.ncbi.nlm.nih.gov/pubmed/33180792
http://dx.doi.org/10.1371/journal.pgen.1009058
work_keys_str_mv AT marzecmarek newinsightsintothefunctionofmammalianargonaute2

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