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A proteomic survey of microtubule-associated proteins in a R402H TUBA1A mutant mouse

Microtubules play a critical role in multiple aspects of neurodevelopment, including the generation, migration and differentiation of neurons. A recurrent mutation (R402H) in the α-tubulin gene TUBA1A is known to cause lissencephaly with cerebellar and striatal phenotypes. Previous work has shown th...

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Detalles Bibliográficos
Autores principales: Leca, Ines, Phillips, Alexander William, Hofer, Iris, Landler, Lukas, Ushakova, Lyubov, Cushion, Thomas David, Dürnberger, Gerhard, Stejskal, Karel, Mechtler, Karl, Keays, David Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660477/
https://www.ncbi.nlm.nih.gov/pubmed/33137126
http://dx.doi.org/10.1371/journal.pgen.1009104