Ikaros antagonizes DNA binding by STAT5 in pre-B cells

The IKZF1 gene, which encodes the Ikaros transcription factor, is frequently deleted or mutated in patients with B-cell precursor acute lymphoblastic leukemias that express oncogenes, like BCR-ABL, which activate the JAK-STAT5 pathway. Ikaros functionally antagonizes the transcriptional programs dow...

Descripción completa

Detalles Bibliográficos
Autores principales: Heizmann, Beate, Le Gras, Stéphanie, Simand, Célestine, Marchal, Patricia, Chan, Susan, Kastner, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660478/
https://www.ncbi.nlm.nih.gov/pubmed/33180866
http://dx.doi.org/10.1371/journal.pone.0242211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660478/
https://www.ncbi.nlm.nih.gov/pubmed/33180866
http://dx.doi.org/10.1371/journal.pone.0242211

Ejemplares similares