High-dose naloxone: Effects by late administration on pain and hyperalgesia following a human heat injury model. A randomized, double-blind, placebo-controlled, crossover trial with an enriched enrollment design

Severe chronic postsurgical pain has a prevalence of 4–10% in the surgical population. The underlying nociceptive mechanisms have not been well characterized. Following the late resolution phase of an inflammatory injury, high-dose μ-opioid-receptor inverse agonists reinstate hypersensitivity to noc...

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Detalles Bibliográficos
Autores principales: Springborg, Anders Deichmann, Jensen, Elisabeth Kjær, Kreilgaard, Mads, Petersen, Morten Aagaard, Papathanasiou, Theodoros, Lund, Trine Meldgaard, Taylor, Bradley Kenneth, Werner, Mads Utke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660513/
https://www.ncbi.nlm.nih.gov/pubmed/33180816
http://dx.doi.org/10.1371/journal.pone.0242169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660513/
https://www.ncbi.nlm.nih.gov/pubmed/33180816
http://dx.doi.org/10.1371/journal.pone.0242169

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