Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation

U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) forms a heterodimeric complex with U2AF2 that is primarily responsible for 3ʹ splice site selection. U2AF1 mutations have been identified in most cancers but are prevalent in Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML), and the most...

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Detalles Bibliográficos
Autores principales: Akef, Abdalla, McGraw, Kathy, Cappell, Steven D., Larson, Daniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660540/
https://www.ncbi.nlm.nih.gov/pubmed/33137094
http://dx.doi.org/10.1371/journal.pbio.3000920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660540/
https://www.ncbi.nlm.nih.gov/pubmed/33137094
http://dx.doi.org/10.1371/journal.pbio.3000920

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