Cross-validated Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Quantitation Protocol for a Pharmaceutical Drug and Its Drug-Target Effects in the Brain Using Time-of-Flight and Fourier Transform Ion Cyclotron Resonance Analyzers

[Image: see text] Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is an established tool in drug development, which enables visualization of drugs and drug metabolites at spatial localizations in tissue sections from different organs. However, robust and accurate qu...

Descripción completa

Detalles Bibliográficos
Autores principales: Källback, Patrik, Vallianatou, Theodosia, Nilsson, Anna, Shariatgorji, Reza, Schintu, Nicoletta, Pereira, Marcela, Barré, Florian, Wadensten, Henrik, Svenningsson, Per, Andrén, Per E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660593/
https://www.ncbi.nlm.nih.gov/pubmed/33086792
http://dx.doi.org/10.1021/acs.analchem.0c03203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660593/
https://www.ncbi.nlm.nih.gov/pubmed/33086792
http://dx.doi.org/10.1021/acs.analchem.0c03203

Ejemplares similares