Cargando…

First Human Use of RUC‐4: A Nonactivating Second‐Generation Small‐Molecule Platelet Glycoprotein IIb/IIIa (Integrin αIIbβ3) Inhibitor Designed for Subcutaneous Point‐of‐Care Treatment of ST‐Segment–Elevation Myocardial Infarction

BACKGROUND: Despite reductions in door‐to‐balloon times for primary coronary intervention, mortality from ST‐segment–elevation myocardial infarction has plateaued. Early pre–primary coronary intervention treatment of ST‐segment–elevation myocardial infarction with glycoprotein IIb/IIIa inhibitors im...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kereiakes, Dean J., Henry, Tim D., DeMaria, Anthony N., Bentur, Ohad, Carlson, Marilyn, Seng Yue, Corinne, Martin, Linda H., Midkiff, Jeff, Mueller, Michele, Meek, Terah, Garza, Deborah, Gibson, C. Michael, Coller, Barry S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660780/ https://www.ncbi.nlm.nih.gov/pubmed/32844723 http://dx.doi.org/10.1161/JAHA.120.016552

Ejemplares similares

Application of Auxiliary VerifyNow Point-of-Care Assays to Assess the Pharmacodynamics of RUC-4, a Novel αIIbβ3 Receptor Antagonist
por: Bentur, Ohad S., et al.
Publicado: (2021)

Preclinical studies of RUC-4, a novel platelet αIIbβ3 antagonist, in non-human primates and with human platelets
por: Vootukuri, Spandana, et al.
Publicado: (2019)

Absence of platelet membrane glycoproteins IIb/IIIa from monocytes
Publicado: (1985)

The Role of Glycoprotein IIb/IIIa Inhibitors- A Promise Not Kept?
por: Kaluski, Edo
Publicado: (2008)

Platelet binding to polymerizing fibrin is avidity driven and requires activated αIIbβ3 but not fibrin cross-linking
por: Buitrago, Lorena, et al.
Publicado: (2021)

Evidence that activation of platelet calpain is induced as a consequence of binding of adhesive ligand to the integrin, glycoprotein IIb-IIIa
Publicado: (1993)

Platelet glycoprotein IIb/IIIa receptor blockade in coronary artery disease
por: Suwaidi, Jassim Al, et al.
Publicado: (2001)

The blocking effect of the glycoprotein IIb/IIIa receptor in the mouse model of asthma
por: Kim, Seo-Hee, et al.
Publicado: (2021)

Is There Still a Role for Glycoprotein IIb/IIIa Antagonists in Acute Coronary Syndromes?
por: Iannetta, Loredana, et al.
Publicado: (2013)

Thrombocytopenia induced by glycoprotein (GP) IIb-IIIa antagonists: about two cases
por: Abdeladim, Salma, et al.
Publicado: (2021)

Receptor GP IIb/IIIa as an Indicator of Risk in Vascular Events
por: Fiodorenko-Dumas, Żanna, et al.
Publicado: (2019)

Effect of Platelet Glycoprotein IIb/IIIa PLA2 Polymorphism on Severity of Pulmonary Thromboembolism
por: Boroujeni, Hamid Rouhi, et al.
Publicado: (2014)

Combined glycoprotein IIb/IIIa inhibitor therapy with ticagrelor for patients with acute coronary syndrome
por: Xie, Zhi-Jiang, et al.
Publicado: (2021)

Diffuse alveolar hemorrhage; An under-diagnosed and rare complication of glycoprotein IIb/IIIa inhibitors
por: Hekmat, Hamidreza, et al.
Publicado: (2022)

Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins
Publicado: (1990)

Thrombin-induced platelet membrane glycoprotein IIb and IIIa complex formation. An electron microscope study
Publicado: (1981)

Acute Cerebral Infarction Following Intravenous Glycoprotein IIb/IIIa Inhibitor for Acute Myocardial Infarction
por: Choi, Woong Gil, et al.
Publicado: (2011)

Glycoprotein IIb/IIIa and P2Y(12) Induction by Oligochitosan Accelerates Platelet Aggregation
por: Periayah, Mercy Halleluyah, et al.
Publicado: (2014)

Adhesive properties of the beta 3 integrins: comparison of GP IIb-IIIa and the vitronectin receptor individually expressed in human melanoma cells
Publicado: (1991)

A prospective analysis of complications related to the use of glycoprotein IIb/IIIa inhibitors in acute coronary syndromes
por: Rocha, RM, et al.
Publicado: (2001)

Influence of glycoprotein IIb/IIIa inhibitors on bleeding events after successful resuscitation and percutaneous coronary intervention
por: Biever, Paul Marc, et al.
Publicado: (2019)

Relationship of Platelet Glycoprotein IIb/IIIa and CD62P With Hypercoagulable State After Oncologic Surgery
por: Zhong, Xin, et al.
Publicado: (2020)

Phosphate reabsorption in the kidney: NaPi-IIb or not IIb
por: Burns, David, et al.
Publicado: (2020)

Early glycoprotein IIb–IIIa inhibitors in primary angioplasty (EGYPT) cooperation: an individual patient data meta-analysis
por: De Luca, G, et al.
Publicado: (2008)

Detection of High-Risk Atherosclerotic Plaques with Ultrasound Molecular Imaging of Glycoprotein IIb/IIIa Receptor on Activated Platelets
por: Guo, Shengcun, et al.
Publicado: (2015)

Safety of Glycoprotein IIb-IIIa Inhibitors Used in Stroke-Related Treatment: A Systematic Review and Meta-Analysis
por: Zhu, Xiaolin, et al.
Publicado: (2020)

One-Year Outcome of Glycoprotein IIb/IIIa Inhibitor Therapy in Patients with Myocardial Infarction-Related Cardiogenic Shock
por: Myrda, Krzysztof, et al.
Publicado: (2021)

The Inhibitory Effects of Protaetia brevitarsis seulensis Larvae Extract on Human Platelet Aggregation and Glycoprotein IIb/IIIa Expression
por: Kwon, Hyuk-Woo, et al.
Publicado: (2023)

Platelet glycoprotein IIb/IIIa inhibitor tirofiban in clopidogrel-naïve patients undergoing elective percutaneous coronary intervention
por: Habibi, Zarina, et al.
Publicado: (2023)

Re-Evaluation of the Survival Paradox Between Stage IIB/IIC and Stage IIIA Colon Cancer
por: Li, Hongbo, et al.
Publicado: (2020)

Morphometric analysis of spread platelets identifies integrin α(IIb)β(3)-specific contractile phenotype
por: Lickert, Sebastian, et al.
Publicado: (2018)

The platelet glycoprotein IIb/IIIa-like protein in human endothelial cells promotes adhesion but not initial attachment to extracellular matrix
Publicado: (1987)

Effects of glycoprotein IIb/IIIa receptor blocker (tirofiban) in acute coronary syndromes angiographic, scintigraphic and molecular biology studies
por: Rizk, A, et al.
Publicado: (2001)

Visualization of Activated Platelets by Targeted Magnetic Resonance Imaging Utilizing Conformation-Specific Antibodies against Glycoprotein IIb/IIIa
por: von zur Muhlen, Constantin, et al.
Publicado: (2009)

Increased Prevalence of Glycoprotein IIb/IIIa Leu 33 Pro Polymorphism in End Stage Renal Disease Patients on Hemodialysis
por: Al-Ali, Amein, et al.
Publicado: (2008)

Glycoprotein IIb/IIIa Inhibitors Use and Outcome after Percutaneous Coronary Intervention for Non-ST Elevation Myocardial Infarction
por: Howard, J. P., et al.
Publicado: (2014)

Effect of Cordycepin-Enriched WIB801C from Cordyceps militaris Suppressing Fibrinogen Binding to Glycoprotein IIb/IIIa
por: Lee, Dong-Ha, et al.
Publicado: (2015)

Case-Control Study of Platelet Glycoprotein Receptor Ib and IIb/IIIa Expression in Patients with Acute and Chronic Cerebrovascular Disease
por: Kraft, Peter, et al.
Publicado: (2015)

Intra-Arterial Glycoprotein IIb/IIIa Inhibitor Treatment for Symptomatic Intracranial Atherosclerotic Stenosis Presenting as Large Vessel Occlusions
por: Srivatsan, Aditya, et al.
Publicado: (2020)

Practicability of Bivalirudin plus Glycoprotein IIb/IIIa Inhibitors in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis
por: Li, Senjie, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fbhhlqkmipnbgod2sit45qbbu6