Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure

BACKGROUND: Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N‐oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine. We investigated the efficacy of dietary withdrawa...

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Detalles Bibliográficos
Autores principales: Organ, Chelsea L., Li, Zhen, Sharp, Thomas E., Polhemus, David J., Gupta, Nilaksh, Goodchild, Traci T., Tang, W. H. Wilson, Hazen, Stanley L., Lefer, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660847/
https://www.ncbi.nlm.nih.gov/pubmed/32390485
http://dx.doi.org/10.1161/JAHA.119.016223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660847/
https://www.ncbi.nlm.nih.gov/pubmed/32390485
http://dx.doi.org/10.1161/JAHA.119.016223

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