Localized Antileptin Therapy Prevents Aortic Root Dilatation and Preserves Left Ventricular Systolic Function in a Murine Model of Marfan Syndrome

BACKGROUND: Marfan syndrome (MFS) is a genetically transmitted connective tissue disorder characterized by aortic root dilatation, dissection, and rupture. Molecularly, MFS pathological features have been shown to be driven by increased angiotensin II in the aortic wall. Using an angiotensin II–driv...

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Detalles Bibliográficos
Autores principales: Fisch, Sudeshna, Bachner‐Hinenzon, Noa, Ertracht, Offir, Guo, Liang, Arad, Yhara, Ben‐Zvi, Danny, Liao, Ronglih, Schneiderman, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660857/
https://www.ncbi.nlm.nih.gov/pubmed/32378446
http://dx.doi.org/10.1161/JAHA.119.014761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660857/
https://www.ncbi.nlm.nih.gov/pubmed/32378446
http://dx.doi.org/10.1161/JAHA.119.014761

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