Transfer learning enables prediction of CYP2D6 haplotype function

Cytochrome P450 2D6 (CYP2D6) is a highly polymorphic gene whose protein product metabolizes more than 20% of clinically used drugs. Genetic variations in CYP2D6 are responsible for interindividual heterogeneity in drug response that can lead to drug toxicity and ineffective treatment, making CYP2D6...

Descripción completa

Detalles Bibliográficos
Autores principales: McInnes, Gregory, Dalton, Rachel, Sangkuhl, Katrin, Whirl-Carrillo, Michelle, Lee, Seung-been, Tsao, Philip S., Gaedigk, Andrea, Altman, Russ B., Woodahl, Erica L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660895/
https://www.ncbi.nlm.nih.gov/pubmed/33137098
http://dx.doi.org/10.1371/journal.pcbi.1008399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660895/
https://www.ncbi.nlm.nih.gov/pubmed/33137098
http://dx.doi.org/10.1371/journal.pcbi.1008399

Ejemplares similares