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Learning and interpreting the gene regulatory grammar in a deep learning framework

Deep neural networks (DNNs) have achieved state-of-the-art performance in identifying gene regulatory sequences, but they have provided limited insight into the biology of regulatory elements due to the difficulty of interpreting the complex features they learn. Several models of how combinatorial b...

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Detalles Bibliográficos
Autores principales: Chen, Ling, Capra, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660921/
https://www.ncbi.nlm.nih.gov/pubmed/33137083
http://dx.doi.org/10.1371/journal.pcbi.1008334