Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors

The ataxia telangiectasia and Rad3-related (ATR) protein kinase is a key regulator of the cellular response to DNA damage. Due to increased amount of replication stress, cancer cells heavily rely on ATR to complete DNA replication and cell cycle progression. Thus, ATR inhibition is an emerging targe...

Descripción completa

Detalles Bibliográficos
Autores principales: Schleicher, Emily M., Dhoonmoon, Ashna, Jackson, Lindsey M., Clements, Kristen E., Stump, Coryn L., Nicolae, Claudia M., Moldovan, George-Lucian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660927/
https://www.ncbi.nlm.nih.gov/pubmed/33137164
http://dx.doi.org/10.1371/journal.pgen.1009176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660927/
https://www.ncbi.nlm.nih.gov/pubmed/33137164
http://dx.doi.org/10.1371/journal.pgen.1009176

Ejemplares similares