A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin

Robust biomarkers of aging have been developed from DNA methylation in humans and more recently, in mice. This study aimed to generate a novel epigenetic clock in rats—a model with unique physical, physiological, and biochemical advantages—by incorporating behavioral data, unsupervised machine learn...

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Detalles Bibliográficos
Autores principales: Levine, Morgan, McDevitt, Ross A, Meer, Margarita, Perdue, Kathy, Di Francesco, Andrea, Meade, Theresa, Farrell, Colin, Thrush, Kyra, Wang, Meng, Dunn, Christopher, Pellegrini, Matteo, de Cabo, Rafael, Ferrucci, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661040/
https://www.ncbi.nlm.nih.gov/pubmed/33179594
http://dx.doi.org/10.7554/eLife.59201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661040/
https://www.ncbi.nlm.nih.gov/pubmed/33179594
http://dx.doi.org/10.7554/eLife.59201

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