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Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexes
Highly charged intrinsically disordered proteins can form complexes with very high affinity in which both binding partners fully retain their disorder and dynamics, exemplified by the positively charged linker histone H1.0 and its chaperone, the negatively charged prothymosin α. Their interaction ex...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661507/ https://www.ncbi.nlm.nih.gov/pubmed/33184256 http://dx.doi.org/10.1038/s41467-020-18859-x |