Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexes

Highly charged intrinsically disordered proteins can form complexes with very high affinity in which both binding partners fully retain their disorder and dynamics, exemplified by the positively charged linker histone H1.0 and its chaperone, the negatively charged prothymosin α. Their interaction ex...

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Detalles Bibliográficos
Autores principales: Sottini, Andrea, Borgia, Alessandro, Borgia, Madeleine B., Bugge, Katrine, Nettels, Daniel, Chowdhury, Aritra, Heidarsson, Pétur O., Zosel, Franziska, Best, Robert B., Kragelund, Birthe B., Schuler, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661507/
https://www.ncbi.nlm.nih.gov/pubmed/33184256
http://dx.doi.org/10.1038/s41467-020-18859-x

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