Cimetidine promotes STUB1-mediated degradation of tumoral FOXP3 by activating PI3K-Akt pathway in gastric cancer

BACKGROUND: Previous studies have confirmed the antitumor effects of cimetidine, while the therapeutic targets and the mechanisms are not yet fully understood. We previously reported the protumoral role of endogenous FOXP3 in gastric cancer (GC), but whether cimetidine plays an antitumor role by tar...

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Detalles Bibliográficos
Autores principales: Zhang, Lu, Li, Qingya, Xu, Jianghao, Sun, Guangli, Xu, Zekuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661906/
https://www.ncbi.nlm.nih.gov/pubmed/33209884
http://dx.doi.org/10.21037/atm-20-6070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661906/
https://www.ncbi.nlm.nih.gov/pubmed/33209884
http://dx.doi.org/10.21037/atm-20-6070

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