Design of Fluorescent Coumarin-Hydroxamic Acid Derivatives as Inhibitors of HDACs: Synthesis, Anti-Proliferative Evaluation and Docking Studies

Coumarin-hydroxamic acid derivatives 7a–k were herein designed with a dual purpose: as antiproliferative agents and fluorescent probes. The compounds were synthesized in moderate yields (30–87%) through a simple methodology, biological evaluation was carried out on prostate (PC3) and breast cancer (...

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Detalles Bibliográficos
Autores principales: García, Santiago, Mercado-Sánchez, Itzel, Bahena, Luis, Alcaraz, Yolanda, García-Revilla, Marco A., Robles, Juvencio, Santos-Martínez, Nancy, Ordaz-Rosado, David, García-Becerra, Rocío, Vazquez, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662212/
https://www.ncbi.nlm.nih.gov/pubmed/33158250
http://dx.doi.org/10.3390/molecules25215134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662212/
https://www.ncbi.nlm.nih.gov/pubmed/33158250
http://dx.doi.org/10.3390/molecules25215134

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