Cargando…

Structural Insights into β-arrestin/CB1 Receptor Interaction: NMR and CD Studies on Model Peptides

Activation of the cannabinoid CB1 receptor induces different cellular signaling cascades through coupling to different effector proteins (G-proteins and β-arrestins), triggering numerous therapeutic effects. Conformational changes and rearrangements at the intracellular domain of this GPCR receptor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morales, Paula, Bruix, Marta, Jiménez, M. Angeles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662265/ https://www.ncbi.nlm.nih.gov/pubmed/33143110 http://dx.doi.org/10.3390/ijms21218111

Ejemplares similares

Biased Coupling to β-Arrestin of Two Common Variants of the CB(2) Cannabinoid Receptor
por: Turu, Gábor, et al.
Publicado: (2021)

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence
por: Ibsen, Mikkel Søes, et al.
Publicado: (2019)

Structural Insights into CB1 Receptor Biased Signaling
por: Al-Zoubi, Rufaida, et al.
Publicado: (2019)

Cannabinoid 1 (CB(1)) receptor arrestin subtype‐selectivity and phosphorylation dependence
por: Manning, Jamie J., et al.
Publicado: (2022)

Biphasic activation of β-arrestin 1 upon interaction with a GPCR revealed by methyl-TROSY NMR
por: Shiraishi, Yutaro, et al.
Publicado: (2021)

Receptor-Arrestin Interactions: The GPCR Perspective
por: Seyedabadi, Mohammad, et al.
Publicado: (2021)

Phosphorylation-induced conformation of β(2)-adrenoceptor related to arrestin recruitment revealed by NMR
por: Shiraishi, Yutaro, et al.
Publicado: (2018)

Distinct activation mechanisms of β-arrestin-1 revealed by (19)F NMR spectroscopy
por: Zhai, Ruibo, et al.
Publicado: (2023)

Structural and functional insights into the G protein-coupled receptors: CB1 and CB2
por: Brust, Christina A., et al.
Publicado: (2023)

Structure of the Neurotensin Receptor 1 in complex with β-arrestin 1
por: Huang, Weijiao, et al.
Publicado: (2020)

NMR characterisation of the minimal interacting regions of centrosomal proteins 4.1R and NuMA1: effect of phosphorylation
por: Treviño, Miguel A, et al.
Publicado: (2010)

Roles of Dopamine D(2) Receptor Subregions in Interactions with β-Arrestin2
por: Zhang, Xiaohan, et al.
Publicado: (2016)

Regulation of N-Formyl Peptide Receptor Signaling and Trafficking by Arrestin-Src Kinase Interaction
por: Wagener, Brant M., et al.
Publicado: (2016)

An Update on Non-CB(1), Non-CB(2) Cannabinoid Related G-Protein-Coupled Receptors
por: Morales, Paula, et al.
Publicado: (2017)

Cannabinoid receptor type 1 (CB(1)R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3
por: Szanda, Gergő, et al.
Publicado: (2023)

NMR Insights into the Structure-Function Relationships in the Binding of Melanocortin Analogues to the MC1R Receptor
por: Morais, Maurício, et al.
Publicado: (2017)

LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1
por: Rodriguiz, Ramona M., et al.
Publicado: (2021)

Improved Split TEV GPCR β-arrestin-2 Recruitment Assays via Systematic Analysis of Signal Peptide and β-arrestin Binding Motif Variants
por: Wu, Yuxin, et al.
Publicado: (2022)

Editorial: G Protein-Coupled Receptor Kinases (GRKs) and β-Arrestins: New Insights Into Disease Regulators
por: Hattori, Yuichi, et al.
Publicado: (2020)

Pharmacological Profile of Nociceptin/Orphanin FQ Receptors Interacting with G-Proteins and β-Arrestins 2
por: Malfacini, D., et al.
Publicado: (2015)

Cariprazine exerts antimanic properties and interferes with dopamine D(2) receptor β-arrestin interactions
por: Gao, Yonglin, et al.
Publicado: (2015)

Allosteric Modulators of the CB(1) Cannabinoid Receptor: A Structural Update Review
por: Morales, Paula, et al.
Publicado: (2016)

Distinct and Shared Roles of β-Arrestin-1 and β-Arrestin-2 on the Regulation of C3a Receptor Signaling in Human Mast Cells
por: Vibhuti, Arpana, et al.
Publicado: (2011)

New Insights into Arrestin Recruitment to GPCRs
por: Spillmann, Martin, et al.
Publicado: (2020)

Novel Cannabinoid Receptor 2 (CB2) Low Lipophilicity Agonists Produce Distinct cAMP and Arrestin Signalling Kinetics without Bias
por: Sharma, Raahul, et al.
Publicado: (2023)

Dual-Color Bioluminescence Analysis for Quantitatively Monitoring G-Protein-Coupled Receptor and β-Arrestin Interactions
por: Kafi, A.K.M., et al.
Publicado: (2011)

β-Arrestin 1’s Interaction with TC45 Attenuates Stat signaling by dephosphorylating Stat to inhibit antimicrobial peptide expression
por: Sun, Jie-Jie, et al.
Publicado: (2016)

Phosphorylated peptide of G protein-coupled receptor induces dimerization in activated arrestin
por: Stadler, Andreas M., et al.
Publicado: (2020)

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc
por: Staus, Dean P., et al.
Publicado: (2020)

β-Arrestin–Biased Angiotensin II Receptor Agonists for COVID-19
por: Manglik, Aashish, et al.
Publicado: (2020)

Not all arrestins are created equal: Therapeutic implications of the functional diversity of the β-arrestins in the heart
por: Lymperopoulos, Anastasios, et al.
Publicado: (2019)

Catalytic activation of β-arrestin by GPCRs
por: Eichel, Kelsie, et al.
Publicado: (2018)

Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension
por: Willets, Jonathon M., et al.
Publicado: (2015)

ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins
por: Matti, Christoph, et al.
Publicado: (2020)

Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants
por: Plouffe, Bianca, et al.
Publicado: (2022)

Cannabigerol Action at Cannabinoid CB(1) and CB(2) Receptors and at CB(1)–CB(2) Heteroreceptor Complexes
por: Navarro, Gemma, et al.
Publicado: (2018)

Interactions between β-arrestin proteins and the cytoskeletal system, and their relevance to neurodegenerative disorders
por: Szénási, Tibor, et al.
Publicado: (2023)

Structure of active β-arrestin1 bound to a G protein-coupled receptor phosphopeptide
por: Shukla, Arun K., et al.
Publicado: (2013)

GPR3 Stimulates Aβ Production via Interactions with APP and β-Arrestin2
por: Nelson, Christopher D., et al.
Publicado: (2013)

Tricyclic Pyrazole-Based Compounds as Useful Scaffolds for Cannabinoid CB(1)/CB(2) Receptor Interaction
por: Asproni, Battistina, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_risbdeptipci7arbd4ap87bj8g