The Pyrazolo[3,4-d]pyrimidine-Based Kinase Inhibitor NVP-BHG712: Effects of Regioisomers on Tumor Growth, Perfusion, and Hypoxia in EphB4-Positive A375 Melanoma Xenografts

In a previous study, EphB4 was demonstrated to be a positive regulator of A375-melanoma growth but a negative regulator of tumor vascularization and perfusion. To distinguish between EphB4 forward and ephrinB2 reverse signaling, we used the commercially available EphB4 kinase inhibitor NVP-BHG712 (N...

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Detalles Bibliográficos
Autores principales: Neuber, Christin, Tröster, Alix, Löser, Reik, Belter, Birgit, Schwalbe, Harald, Pietzsch, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662635/
https://www.ncbi.nlm.nih.gov/pubmed/33153234
http://dx.doi.org/10.3390/molecules25215115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662635/
https://www.ncbi.nlm.nih.gov/pubmed/33153234
http://dx.doi.org/10.3390/molecules25215115

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