Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses

Rho GTPase signaling promotes proliferation, invasion, and metastasis in a broad spectrum of cancers. Rho GTPase activity is regulated by the deleted in liver cancer (DLC) family of bona fide tumor suppressors which directly inactivate Rho GTPases by stimulating GTP hydrolysis. In addition to a RhoG...

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Detalles Bibliográficos
Autores principales: Holub, Ashton S., Bouley, Renee A., Petreaca, Ruben C., Husbands, Aman Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662654/
https://www.ncbi.nlm.nih.gov/pubmed/33142932
http://dx.doi.org/10.3390/ijms21218175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662654/
https://www.ncbi.nlm.nih.gov/pubmed/33142932
http://dx.doi.org/10.3390/ijms21218175

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