Mimicking the Nucleosomal Context in Peptide-Based Binders of a H3K36me Reader Increases Binding Affinity While Altering the Binding Mode

Targeting of proteins in the histone modification machinery has emerged as a promising new direction to fight disease. The search for compounds that inhibit proteins that readout histone modification has led to several new epigenetic drugs, mostly for proteins involved in recognition of acetylated l...

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Detalles Bibliográficos
Autores principales: Horn, Velten, Jongkees, Seino A. K., van Ingen, Hugo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662849/
https://www.ncbi.nlm.nih.gov/pubmed/33114657
http://dx.doi.org/10.3390/molecules25214951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662849/
https://www.ncbi.nlm.nih.gov/pubmed/33114657
http://dx.doi.org/10.3390/molecules25214951

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