Sphingosine 1-Phosphate Induces Cyclooxygenase-2/Prostaglandin E(2) Expression via PKCα-dependent Mitogen-Activated Protein Kinases and NF-κB Cascade in Human Cardiac Fibroblasts

In the regions of tissue injuries and inflammatory diseases, sphingosine 1-phosphate (S1P), a proinflammatory mediator, is increased. S1P may induce the upregulation of cyclooxygenase-2 (COX-2)/prostaglandin E(2) (PGE(2)) system in various types of cells to exacerbate heart inflammation. However, th...

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Detalles Bibliográficos
Autores principales: Yang, Chien-Chung, Hsiao, Li-Der, Su, Mei-Hsiu, Yang, Chuen-Mao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662885/
https://www.ncbi.nlm.nih.gov/pubmed/33192511
http://dx.doi.org/10.3389/fphar.2020.569802

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662885/
https://www.ncbi.nlm.nih.gov/pubmed/33192511
http://dx.doi.org/10.3389/fphar.2020.569802

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