Effects of Modifying Thioflavin T at the N(3)-Position on Its G4 Binding and Fluorescence Emission

We previously synthesized thioflavin T (ThT) with a hydroxyethyl group introduced at the N(3)-position (ThT-HE), which binds predominantly to the parallel G-quadruplex (G4) structure found in c-Myc and emits strong fluorescence. In this study, to investigate the effects of introduced substituents on...

Descripción completa

Detalles Bibliográficos
Autores principales: Kataoka, Yuka, Fujita, Hiroto, Endoh, Tamaki, Sugimoto, Naoki, Kuwahara, Masayasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663003/
https://www.ncbi.nlm.nih.gov/pubmed/33114506
http://dx.doi.org/10.3390/molecules25214936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663003/
https://www.ncbi.nlm.nih.gov/pubmed/33114506
http://dx.doi.org/10.3390/molecules25214936

Ejemplares similares