Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a Beta-Amyloidosis Mouse Model

Background: ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein) are co-localized at the blood-brain barrier (BBB), where they restrict the brain distribution of many different drugs. Moreover, ABCB1 and possibly ABCG2 play a role in Alzheimer’s disease (AD) by mediating the brain cle...

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Detalles Bibliográficos
Autores principales: Wanek, Thomas, Zoufal, Viktoria, Brackhan, Mirjam, Krohn, Markus, Mairinger, Severin, Filip, Thomas, Sauberer, Michael, Stanek, Johann, Pekar, Thomas, Pahnke, Jens, Langer, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663372/
https://www.ncbi.nlm.nih.gov/pubmed/33153231
http://dx.doi.org/10.3390/ijms21218245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663372/
https://www.ncbi.nlm.nih.gov/pubmed/33153231
http://dx.doi.org/10.3390/ijms21218245

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