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Synthetic Makaluvamine Analogs Decrease c-Kit Expression and Are Cytotoxic to Neuroendocrine Tumor Cells
In an effort to discover viable systemic chemotherapeutic agents for neuroendocrine tumors (NETs), we screened a small library of 18 drug-like compounds obtained from the Velu lab against pulmonary (H727) and thyroid (MZ-CRC-1 and TT) neuroendocrine tumor-derived cell lines. Two potent lead compound...
Autores principales: | Aburjania, Zviadi, Whitt, Jason D., Jang, Samuel, Nadkarni, Dwayaja H., Chen, Herbert, Rose, J. Bart, Velu, Sadanandan E., Jaskula-Sztul, Renata |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663375/ https://www.ncbi.nlm.nih.gov/pubmed/33114525 http://dx.doi.org/10.3390/molecules25214940 |
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