Empagliflozin Inhibits Basal and IL-1β-Mediated MCP-1/CCL2 and Endothelin-1 Expression in Human Proximal Tubular Cells

SGLT2 inhibitors (SGLT2i) slow the progression of chronic kidney disease; however, evidence for the underlying molecular mechanisms is scarce. We investigated SGLT2i-mediated effects on differential gene expression in two independent human proximal tubular cell (HPTC) lines (HK-2 and RPTEC/TERT1) at...

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Detalles Bibliográficos
Autores principales: Pirklbauer, Markus, Bernd, Maximilian, Fuchs, Lisa, Staudinger, Petra, Corazza, Ulrike, Leierer, Johannes, Mayer, Gert, Schramek, Herbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663377/
https://www.ncbi.nlm.nih.gov/pubmed/33139635
http://dx.doi.org/10.3390/ijms21218189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663377/
https://www.ncbi.nlm.nih.gov/pubmed/33139635
http://dx.doi.org/10.3390/ijms21218189

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