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In Vivo Pre-Instructed HSCs Robustly Execute Asymmetric Cell Divisions In Vitro

Hematopoietic stem cells (HSCs) are responsible for life-long production of all mature blood cells. Under homeostasis, HSCs in their native bone marrow niches are believed to undergo asymmetric cell divisions (ACDs), with one daughter cell maintaining HSC identity and the other committing to differe...

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Detalles Bibliográficos
Autores principales: Girotra, Mukul, Trachsel, Vincent, Roch, Aline, Lutolf, Matthias P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663432/
https://www.ncbi.nlm.nih.gov/pubmed/33153113
http://dx.doi.org/10.3390/ijms21218225