Cholesterol-Rich Microdomains Contribute to PAR1 Signaling in Platelets Despite a Weak Localization of the Receptor in These Microdomains

Platelet protease-activated receptor 1 (PAR1) is a cell surface G-protein-coupled receptor (GPCR) that acts as a thrombin receptor promoting platelet aggregation. Targeting the PAR1 pathway by vorapaxar, a PAR1 antagonist, leads to a reduction in ischemic events in cardiovascular patients with a his...

Descripción completa

Detalles Bibliográficos
Autores principales: Rabani, Vahideh, Lagoutte-Renosi, Jennifer, Series, Jennifer, Valot, Benoit, Xuereb, Jean-Marie, Davani, Siamak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663584/
https://www.ncbi.nlm.nih.gov/pubmed/33138025
http://dx.doi.org/10.3390/ijms21218065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663584/
https://www.ncbi.nlm.nih.gov/pubmed/33138025
http://dx.doi.org/10.3390/ijms21218065

Ejemplares similares