Structure–Activity Relationship of Aloperine Derivatives as New Anti–Liver Fibrogenic Agents

Twenty-seven novel 12N-substituted aloperine derivatives were synthesized and investigated for their inhibitory effects on collagen α1 (I) (COL1A1) promotor in human hepatic stellate LX-2 cells, taking aloperine (1) as the hit. A structure-activity relationship (SAR) study disclosed that the introdu...

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Detalles Bibliográficos
Autores principales: Wang, Kun, Guo, Zhihao, Bao, Yunyang, Pang, Yudong, Li, Yinghong, He, Hongwei, Song, Danqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663597/
https://www.ncbi.nlm.nih.gov/pubmed/33121156
http://dx.doi.org/10.3390/molecules25214977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663597/
https://www.ncbi.nlm.nih.gov/pubmed/33121156
http://dx.doi.org/10.3390/molecules25214977

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