In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice

Post-translational epigenetic modifications take place in mouse neurons of the dentate gyrus (DG) with age. Here, we report that age-dependent reduction in H3K9 trimethylation (H3K9me3) is prevented by cyclic induction of the Yamanaka factors used for cell reprogramming. Interestingly, Yamanaka fact...

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Detalles Bibliográficos
Autores principales: Rodríguez-Matellán, Alberto, Alcazar, Noelia, Hernández, Félix, Serrano, Manuel, Ávila, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663782/
https://www.ncbi.nlm.nih.gov/pubmed/33096049
http://dx.doi.org/10.1016/j.stemcr.2020.09.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663782/
https://www.ncbi.nlm.nih.gov/pubmed/33096049
http://dx.doi.org/10.1016/j.stemcr.2020.09.010

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