PARP Inhibitor Olaparib Causes No Potentiation of the Bleomycin Effect in VERO Cells, Even in the Presence of Pooled ATM, DNA-PK, and LigIV Inhibitors

Poly(ADP-ribosyl)polymerase (PARP) synthesizes poly(ADP-ribose) (PAR), which is anchored to proteins. PAR facilitates multiprotein complexes’ assembly. Nuclear PAR affects chromatin’s structure and functions, including transcriptional regulation. In response to stress, particularly genotoxic stress,...

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Detalles Bibliográficos
Autores principales: Perini, Valentina, Schacke, Michelle, Liddle, Pablo, Vilchez-Larrea, Salomé, Keszenman, Deborah J., Lafon-Hughes, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663819/
https://www.ncbi.nlm.nih.gov/pubmed/33167404
http://dx.doi.org/10.3390/ijms21218288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663819/
https://www.ncbi.nlm.nih.gov/pubmed/33167404
http://dx.doi.org/10.3390/ijms21218288

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