Discovery of Oxazol-2-amine Derivatives as Potent Novel FLT3 Inhibitors

Internal tandem duplication (ITD) of FMS-like tyrosine kinase 3 (FLT3) is the most common mutation in patients with acute myeloid leukemia (AML). FLT3-ITD(+) induces constitutive activation of FLT3, causing an abnormally rapid proliferation of cancer cells. In this study, we identified novel FLT3 in...

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Detalles Bibliográficos
Autores principales: Kim, Hyo Jeong, Ryu, Hwani, Song, Jie-Young, Hwang, Sang-Gu, Jalde, Shivakumar S., Choi, Hyun-Kyung, Ahn, Jiyeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663913/
https://www.ncbi.nlm.nih.gov/pubmed/33167505
http://dx.doi.org/10.3390/molecules25215154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663913/
https://www.ncbi.nlm.nih.gov/pubmed/33167505
http://dx.doi.org/10.3390/molecules25215154

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