Quantitative Structure–Mutation–Activity Relationship Tests (QSMART) model for protein kinase inhibitor response prediction

BACKGROUND: Protein kinases are a large family of druggable proteins that are genomically and proteomically altered in many human cancers. Kinase-targeted drugs are emerging as promising avenues for personalized medicine because of the differential response shown by altered kinases to drug treatment...

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Detalles Bibliográficos
Autores principales: Huang, Liang-Chin, Yeung, Wayland, Wang, Ye, Cheng, Huimin, Venkat, Aarya, Li, Sheng, Ma, Ping, Rasheed, Khaled, Kannan, Natarajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664030/
https://www.ncbi.nlm.nih.gov/pubmed/33183223
http://dx.doi.org/10.1186/s12859-020-03842-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664030/
https://www.ncbi.nlm.nih.gov/pubmed/33183223
http://dx.doi.org/10.1186/s12859-020-03842-6

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