Exendin-4 restores airway mucus homeostasis through the GLP1R-PKA-PPARγ-FOXA2-phosphatase signaling

Goblet cell hyperplasia and metaplasia and excessive mucus are prominent pathologies of chronic airway diseases such as chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and chronic bronchitis. Chronic infection by respiratory pathogens, including Pseudomonas aeruginosa, exacerbate...

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Detalles Bibliográficos
Autores principales: Choi, Woosuk, Choe, Shawn, Lin, Jingjun, Borchers, Michael T, Kosmider, Beata, Vassallo, Robert, Limper, Andrew H., Lau, Gee W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664156/
https://www.ncbi.nlm.nih.gov/pubmed/32034274
http://dx.doi.org/10.1038/s41385-020-0262-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664156/
https://www.ncbi.nlm.nih.gov/pubmed/32034274
http://dx.doi.org/10.1038/s41385-020-0262-1

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