Synthesis and Antiviral Activity of a Series of 2′-C-Methyl-4′-thionucleoside Monophosphate Prodrugs

The NS5B RNA-dependent RNA polymerase of the hepatitis C virus (HCV) is a validated target for nucleoside antiviral drug therapy. We endeavored to synthesize and test a series of 4′-thionucleosides with a monophosphate prodrug moiety for their antiviral activity against HCV and other related viruses...

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Detalles Bibliográficos
Autores principales: Dentmon, Zackery W., Kaiser, Thomas M., Liotta, Dennis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664256/
https://www.ncbi.nlm.nih.gov/pubmed/33171951
http://dx.doi.org/10.3390/molecules25215165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664256/
https://www.ncbi.nlm.nih.gov/pubmed/33171951
http://dx.doi.org/10.3390/molecules25215165

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