Design of Anticancer 2,4-Diaminopyrimidines as Novel Anoctamin 1 (ANO1) Ion Channel Blockers

Pyrimidine is a privileged scaffold in many synthetic compounds exhibiting diverse pharmacological activities, and is used for therapeutic applications in a broad spectrum of human diseases. In this study, we prepared a small set of pyrimidine libraries based on the structure of two hit compounds th...

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Detalles Bibliográficos
Autores principales: Kim, Taewoo, Cho, Sinyoung, Oh, Haejun, Hur, Joonseong, Kim, Haedong, Choi, Young-Ho, Jeon, Seongho, Yang, Young Duk, Kim, Seok-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664333/
https://www.ncbi.nlm.nih.gov/pubmed/33172169
http://dx.doi.org/10.3390/molecules25215180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664333/
https://www.ncbi.nlm.nih.gov/pubmed/33172169
http://dx.doi.org/10.3390/molecules25215180

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