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Mitochondrial dysfunction and pancreatic islet β-cell failure (Review)

Pancreatic β-cells are the only source of insulin in humans. Mitochondria uses pyruvate to produce ATP as an intermediate link between glucose intake and insulin secretion in β-cells, in a process known as glucose-stimulated insulin secretion (GSIS). Previous studies have demonstrated that GSIS is n...

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Detalles Bibliográficos
Autores principales: Sha, Wenxin, Hu, Fei, Bu, Shizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664595/
https://www.ncbi.nlm.nih.gov/pubmed/33199991
http://dx.doi.org/10.3892/etm.2020.9396