Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at IKZF1 and IKZF3 in Systemic Lupus Erythematosus

Background: Prioritizing tag-SNPs carried on extended risk haplotypes at susceptibility loci for common disease is a challenge. Methods: We utilized trans-ancestral exclusion mapping to reduce risk haplotypes at IKZF1 and IKZF3 identified in multiple ancestries from SLE GWAS and ImmunoChip datasets....

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Detalles Bibliográficos
Autores principales: Vyse, Timothy J., Cunninghame Graham, Deborah S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664943/
https://www.ncbi.nlm.nih.gov/pubmed/33182226
http://dx.doi.org/10.3390/ijms21218383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664943/
https://www.ncbi.nlm.nih.gov/pubmed/33182226
http://dx.doi.org/10.3390/ijms21218383

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