Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity

The Mus81-Mms4 nuclease is activated in G2/M via Mms4 phosphorylation to allow resolution of persistent recombination structures. However, the fate of the activated phosphorylated Mms4 remains unknown. Here we find that Mms4 is engaged by (poly)SUMOylation and ubiquitylation and targeted for proteas...

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Detalles Bibliográficos
Autores principales: Waizenegger, Anja, Urulangodi, Madhusoodanan, Lehmann, Carl P., Reyes, Teresa Anne Clarisse, Saugar, Irene, Tercero, José Antonio, Szakal, Barnabas, Branzei, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665200/
https://www.ncbi.nlm.nih.gov/pubmed/33184279
http://dx.doi.org/10.1038/s41467-020-19503-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665200/
https://www.ncbi.nlm.nih.gov/pubmed/33184279
http://dx.doi.org/10.1038/s41467-020-19503-4

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