A path towards SARS-CoV-2 attenuation: metabolic pressure on CTP synthesis rules the virus evolution

In the context of the COVID-19 pandemic, we describe here the singular metabolic background that constrains enveloped RNA viruses to evolve towards likely attenuation in the long term, possibly after a step of increased pathogenicity. Cytidine triphosphate (CTP) is at the crossroad of the processes...

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Detalles Bibliográficos
Autores principales: Ou, Zhihua, Ouzounis, Christos, Wang, Daxi, Sun, Wanying, Li, Junhua, Chen, Weijun, Marlière, Philippe, Danchin, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665462/
https://www.ncbi.nlm.nih.gov/pubmed/33125064
http://dx.doi.org/10.1093/gbe/evaa229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665462/
https://www.ncbi.nlm.nih.gov/pubmed/33125064
http://dx.doi.org/10.1093/gbe/evaa229

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