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Antidepressive effect of an inward rectifier K(+) channel blocker peptide, tertiapin-RQ

Renal outer medullary K(+) channel, ROMK (Kir1.1, kcnj1) is expressed in the kidney and brain, but its role in the central nervous system remains unknown. Recent studies suggested an involvement of the ROMK channel in mental diseases. Tertiapin (TPN) is a European honey bee venom peptide and is repo...

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Detalles Bibliográficos
Autores principales: Okada, Masayoshi, Kozaki, Ikkou, Honda, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665585/
https://www.ncbi.nlm.nih.gov/pubmed/33186384
http://dx.doi.org/10.1371/journal.pone.0233815