GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis

Ribosome-associated quality control pathways respond to defects in translational elongation to recycle arrested ribosomes and degrade aberrant polypeptides and mRNAs. Loss of a tRNA gene leads to ribosomal pausing that is resolved by the translational GTPase GTPBP2, and in its absence causes neuron...

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Detalles Bibliográficos
Autores principales: Terrey, Markus, Adamson, Scott I, Gibson, Alana L, Deng, Tianda, Ishimura, Ryuta, Chuang, Jeffrey H, Ackerman, Susan L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665888/
https://www.ncbi.nlm.nih.gov/pubmed/33186095
http://dx.doi.org/10.7554/eLife.62731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665888/
https://www.ncbi.nlm.nih.gov/pubmed/33186095
http://dx.doi.org/10.7554/eLife.62731

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