eIF4E S209 phosphorylation licenses myc- and stress-driven oncogenesis

To better understand a role of eIF4E S209 in oncogenic translation, we generated EIF4E(S209A/+) heterozygous knockin (4EKI) HCT 116 human colorectal cancer (CRC) cells. 4EKI had little impact on total eIF4E levels, cap binding or global translation, but markedly reduced HCT 116 cell growth in sphero...

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Detalles Bibliográficos
Autores principales: Ruan, Hang, Li, Xiangyun, Xu, Xiang, Leibowitz, Brian J, Tong, Jingshan, Chen, Lujia, Ao, Luoquan, Xing, Wei, Luo, Jianhua, Yu, Yanping, Schoen, Robert E, Sonenberg, Nahum, Lu, Xinghua, Zhang, Lin, Yu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665890/
https://www.ncbi.nlm.nih.gov/pubmed/33135632
http://dx.doi.org/10.7554/eLife.60151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665890/
https://www.ncbi.nlm.nih.gov/pubmed/33135632
http://dx.doi.org/10.7554/eLife.60151

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