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DNA mismatches reveal conformational penalties in protein-DNA recognition

Transcription factors (TF) recognize specific genomic sequences to regulate complex gene expression programs. Although it is well established that TFs bind specific DNA sequences using a combination of base readout and shape recognition, some fundamental aspects of protein-DNA binding remain poorly...

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Detalles Bibliográficos
Autores principales:	Afek, Ariel, Shi, Honglue, Rangadurai, Atul, Sahay, Harshit, Senitzki, Alon, Xhani, Suela, Fang, Mimi, Salinas, Raul, Mielko, Zachery, Pufall, Miles A., Poon, Gregory M.K., Haran, Tali E., Schumacher, Maria A., Al-Hashimi, Hashim M., Gordan, Raluca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666076/ https://www.ncbi.nlm.nih.gov/pubmed/33087930 http://dx.doi.org/10.1038/s41586-020-2843-2

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