A computational method for detection of ligand-binding proteins from dose range thermal proteome profiles

Detecting ligand-protein interactions in living cells is a fundamental challenge in molecular biology and drug research. Proteome-wide profiling of thermal stability as a function of ligand concentration promises to tackle this challenge. However, current data analysis strategies use preset threshol...

Descripción completa

Detalles Bibliográficos
Autores principales: Kurzawa, Nils, Becher, Isabelle, Sridharan, Sindhuja, Franken, Holger, Mateus, André, Anders, Simon, Bantscheff, Marcus, Huber, Wolfgang, Savitski, Mikhail M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666118/
https://www.ncbi.nlm.nih.gov/pubmed/33188197
http://dx.doi.org/10.1038/s41467-020-19529-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666118/
https://www.ncbi.nlm.nih.gov/pubmed/33188197
http://dx.doi.org/10.1038/s41467-020-19529-8

Ejemplares similares