Exosome markers of LRRK2 kinase inhibition

Hyper-activated LRRK2 is linked to Parkinson’s disease susceptibility and progression. Quantitative measures of LRRK2 inhibition, especially in the brain, maybe critical in the development of successful LRRK2-targeting therapeutics. In this study, two different brain-penetrant and selective LRRK2 sm...

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Detalles Bibliográficos
Autores principales: Wang, Shijie, Kelly, Kaela, Brotchie, Jonathan M., Koprich, James B., West, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666125/
https://www.ncbi.nlm.nih.gov/pubmed/33298972
http://dx.doi.org/10.1038/s41531-020-00138-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666125/
https://www.ncbi.nlm.nih.gov/pubmed/33298972
http://dx.doi.org/10.1038/s41531-020-00138-7

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