YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA

YTH Domain Containing 1 (YTHDC1) is one of the m(6)A readers that is essential for oocyte development and tumor progression. The role of YTHDC1 in neuronal survival and ischemic stroke is unknown. Here, we found that YTHDC1 was unregulated in the early phase of ischemic stroke. Knockdown of YTHDC1 e...

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Detalles Bibliográficos
Autores principales: Zhang, Zhaolong, Wang, Qiuhan, Zhao, Xiaolong, Shao, Liming, Liu, Guoping, Zheng, Xuan, Xie, Lingling, Zhang, Yan, Sun, Chengjian, Xu, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666223/
https://www.ncbi.nlm.nih.gov/pubmed/33188203
http://dx.doi.org/10.1038/s41419-020-03186-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666223/
https://www.ncbi.nlm.nih.gov/pubmed/33188203
http://dx.doi.org/10.1038/s41419-020-03186-2

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