Cell-free synthesis of the hirudin variant 1 of the blood-sucking leech Hirudo medicinalis

Synthesis and purification of peptide drugs for medical applications is a challenging task. The leech-derived factor hirudin is in clinical use as an alternative to heparin in anticoagulatory therapies. So far, recombinant hirudin is mainly produced in bacterial or yeast expression systems. We descr...

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Detalles Bibliográficos
Autores principales: Wüstenhagen, Doreen A., Lukas, Phil, Müller, Christian, Aubele, Simone A., Hildebrandt, Jan-Peter, Kubick, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666225/
https://www.ncbi.nlm.nih.gov/pubmed/33188246
http://dx.doi.org/10.1038/s41598-020-76715-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666225/
https://www.ncbi.nlm.nih.gov/pubmed/33188246
http://dx.doi.org/10.1038/s41598-020-76715-w

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