In Vitro and In Vivo Rat Model Assessments of the Effects of Vonoprazan on the Pharmacokinetics of Venlafaxine

PURPOSE: The purpose of the present study was to investigate the effects of vonoprazan on the pharmacokinetics of venlafaxine in vitro and in vivo. METHODS: The mechanism underlying the inhibitory effect of vonoprazan on venlafaxine was investigated using rat liver microsomes. In vitro, the inhibiti...

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Detalles Bibliográficos
Autores principales: Chen, Feifei, Jiang, Hui, Xu, Jia, Wang, Shuanghu, Meng, Deru, Geng, Peiwu, Dai, Dapeng, Zhou, Quan, Zhou, Yunfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667002/
https://www.ncbi.nlm.nih.gov/pubmed/33204067
http://dx.doi.org/10.2147/DDDT.S276704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667002/
https://www.ncbi.nlm.nih.gov/pubmed/33204067
http://dx.doi.org/10.2147/DDDT.S276704

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